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Drug-target interaction and classification of drugs

55 questions on Drug-target interaction and classification of drugs from the Chemistry in Everyday Life chapter: 10 NEET level, 22 JEE Main, 23 JEE Advanced. Each one opens with its answer and solution.

Practice this topic All Chemistry in Everyday Life topics

A molecule that binds at the active site of an enzyme and so stops the natural substrate from attaching is called NEET level
Receptor proteins that serve as drug targets are best described as NEET level
A drug that mimics the natural messenger by binding to a receptor and switching it on is called an NEET level
Grouping drugs as analgesics, antipyretics, antacids and antiseptics is a classification based on NEET level
The treatment of diseases using chemicals is called NEET level
An allosteric inhibitor of an enzyme acts by NEET level
If a person takes a drug in an amount far above its therapeutic dose, the drug generally acts as NEET level
Assertion (A): Competitive inhibition of an enzyme can be reduced by increasing the substrate concentration. Reason (R): The competitive inhibitor and the subst... JEE Main level
Match List I with List II. List I: P agonist; Q receptor antagonist; R competitive enzyme inhibitor; S allosteric enzyme inhibitor. List II: 1 binds a receptor ... JEE Main level
According to the standard NCERT classification, which of the following groupings of drugs is made on the basis of drug action? JEE Main level
Drugs X, Y and Z all contain the sulphonamide unit and are used for different purposes. Putting X, Y and Z in one class is a classification based on JEE Main level
Which set of interactions is mainly responsible for the reversible binding of a drug to its target? JEE Main level
A lead compound is JEE Main level
A drug designed to bind only one receptor subtype is expected to give fewer side effects mainly because JEE Main level
Which statement is correct? JEE Main level
Cimetidine reduces the secretion of acid in the stomach by preventing histamine from binding to its receptors in the stomach wall. Cimetidine is therefore best ... JEE Main level
The inhibition of an enzyme by compound I is not reduced when the substrate concentration is raised 100-fold, and I has no structural resemblance to the substra... JEE Main level
Which statement about an agonist and an antagonist of the same receptor is correct? JEE Main level
Classifying drugs as 'acting on nucleic acids' and 'acting on proteins' is a classification based on JEE Main level
Select all correct statements about competitive enzyme inhibitors. JEE Main level
Select all correct statements about receptors and their ligands. JEE Main level
According to the standard NCERT classification, select all correct pairs of drug group and basis of classification. JEE Main level
Three inhibitors were tested on one enzyme. P: the inhibition falls steadily as the substrate concentration is raised 50-fold, and P is structurally similar to ... JEE Advanced level
Sulphanilamide, H2N-C6H4-SO2NH2, resembles p-aminobenzoic acid, a substrate used by bacteria to make folic acid. Which description of sulphanilamide is correct? JEE Advanced level
A drug K is described in three ways: (1) it is an anti-ulcer drug; (2) it blocks the action of histamine; (3) it binds the H2 receptor protein in the stomach wa... JEE Advanced level
Drug D relieves the sneezing of hay fever but does not reduce gastric acid. Drug E lowers gastric acid secretion but does not relieve hay fever. Both act by blo... JEE Advanced level
A reversible competitive antagonist A and an agonist G bind the same receptor site. In the presence of a fixed amount of A, what happens to the response when th... JEE Advanced level
Drug A binds the active-site serine of an enzyme through a covalent bond. Drug B binds the same site through hydrogen bonds and van der Waals forces. Which comp... JEE Advanced level
Assertion (A): Every drug that works by inhibiting an enzyme must bind it through covalent bonds. Reason (R): Covalent binding of an inhibitor at the active sit... JEE Advanced level
Match List I with List II. List I: P sulphonamides; Q antipyretics; R antihistamines; S drugs acting on nucleic acids. List II: 1 pharmacological effect; 2 drug... JEE Advanced level
Lead compound X is active at 5 mg per kg but toxic at 8 mg per kg. After structural modification the product X' is active at 5 mg per kg and toxic only above 80... JEE Advanced level
A messenger molecule M activates receptor R. Drug Y has a structure partly like M, binds R more tightly than M does, and does not change the shape of R in the w... JEE Advanced level
Select all correct statements about enzyme inhibitors. JEE Advanced level
The table summarises three drugs tested on receptor types R1 and R2. Drug 1: binds R1 and gives a response; does not bind R2. Drug 2: binds R1, gives no respons... JEE Advanced level
Drug W has a minimum effective dose of 4 mg and a toxic dose of 40 mg. Select all correct statements, taking the therapeutic range as 4 mg to 40 mg. JEE Advanced level
Select all correct statements about how drugs bind their targets. JEE Advanced level
Select all correct statements about the classification of drugs. JEE Advanced level
Aspirin is classified as a NEET level
Which drug prevents the interaction of histamine with the receptors in the stomach wall, thereby reducing acid release? NEET level
Morphine is an example of a NEET level
A drug binds to an enzyme at a site other than the active site, and this binding changes the shape of the active site so that the substrate can no longer bind. ... JEE Main level
Grouping drugs as sulphonamides because they share a common sulphonamide core structure is a classification based on JEE Main level
Which of the following is NOT a narcotic analgesic? JEE Main level
According to the standard NCERT treatment, which of the following is a correct statement about phenol? JEE Main level
Which of the following antibiotics is bactericidal? JEE Main level
Assertion (A): Aluminium hydroxide or magnesium hydroxide is preferred to sodium hydrogencarbonate for long-term use as an antacid. Reason (R): Excess hydrogenc... JEE Main level
Select the correct statements. JEE Main level
A drug is the acetyl derivative of salicylic acid. It inhibits the synthesis of prostaglandins, relieves pain and fever, and in low doses reduces blood clotting... JEE Advanced level
According to the standard NCERT treatment, penicillin G is effective mainly against Gram-positive bacteria and kills them, while ofloxacin acts against both Gra... JEE Advanced level
Drug P binds to a receptor site and produces the same response as the natural messenger. Drug Q binds to the same receptor site but produces no response. Which ... JEE Advanced level
A combined oral contraceptive contains norethindrone and ethynylestradiol. Which statement about these is correct? JEE Advanced level
A patient with depression has low noradrenaline levels because an enzyme degrades it too fast. A drug that inhibits this enzyme is given. The drug is classified... JEE Advanced level
Select the correct statements about enzyme inhibition by drugs. JEE Advanced level
Select the correctly matched drug and class. JEE Advanced level
Select the correct statements about antiseptics and disinfectants. JEE Advanced level