JEE Main levelSingle correct optionDifficulty 2 of 3el012
Which set of interactions is mainly responsible for the reversible binding of a drug to its target?
Ahydrogen bonds, ionic attraction, dipole-dipole forces and van der Waals forces
Bonly covalent bonds to residues of the target
Cmetallic bonds and covalent bonds
Dpeptide bonds formed with the target
Answer: A
Reversible binding relies on weak non-covalent interactions: hydrogen bonding, ionic attraction, dipole-dipole and van der Waals forces. Covalent binding is strong and usually irreversible.