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JEE Main levelSingle correct optionDifficulty 2 of 3el014

A drug designed to bind only one receptor subtype is expected to give fewer side effects mainly because

  1. Ait is changed to an inert compound in the liver
  2. Bother receptor subtypes have binding sites of different shape and do not bind it well
  3. Cit must be given in a much larger dose
  4. Dit binds every receptor equally weakly

Answer: B

Receptor selectivity comes from the shape and chemistry of the binding site. A drug matched to one subtype will not fit other subtypes, so it does not trigger or block the unintended pathways that cause side effects.
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