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JEE Advanced levelSingle correct optionDifficulty 3 of 3el027

A reversible competitive antagonist A and an agonist G bind the same receptor site. In the presence of a fixed amount of A, what happens to the response when the concentration of G is made very large? What would be expected if A instead bonded covalently and permanently to that site?

  1. AResponse restored toward the maximum; not restored
  2. BNot restored; restored
  3. CRestored in both cases
  4. DNot restored in either case

Answer: A

A reversible antagonist can be outcompeted by a large excess of G, so the response returns toward its maximum. A covalently bound antagonist cannot be displaced, so extra agonist cannot restore the response.
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