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JEE Advanced levelOne or more correct optionsDifficulty 3 of 3el163

Select the correct statements about enzyme inhibition by drugs.

  1. AA competitive inhibitor resembles the substrate and competes for the active site.
  2. BCompetitive inhibition cannot be reduced by increasing the substrate concentration.
  3. CAn allosteric inhibitor changes the shape of the active site after binding elsewhere on the enzyme.
  4. DA drug that blocks substrate binding can act as an enzyme inhibitor.

Answer: A, C, D

A competitive inhibitor mimics the substrate and occupies the active site, and an allosteric inhibitor binds elsewhere and distorts the active site, so statements 1 and 3 are true. Blocking substrate binding defines enzyme inhibition (4). Higher substrate concentration can out-compete a competitive inhibitor, so statement 2 is false.
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