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JEE Advanced levelOne or more correct optionsDifficulty 3 of 3el034

The table summarises three drugs tested on receptor types R1 and R2. Drug 1: binds R1 and gives a response; does not bind R2. Drug 2: binds R1, gives no response and lowers the response to the natural messenger; does not bind R2. Drug 3: binds both R1 and R2 and gives a response at each. Select all correct inferences.

  1. ADrug 3 is less selective than Drug 1.
  2. BDrug 1 is an antagonist at R1.
  3. CDrug 2 is an antagonist at R1.
  4. DDrug 2 given with the natural messenger will reduce the R1 response.

Answer: A, C, D

Drug 1 activates R1 so it is an agonist, not an antagonist (b false). Drug 2 occupies R1 without response and blocks the messenger, so it is an antagonist and lowers the response (c, d true). Drug 3 acts at two receptor types while Drug 1 acts at one, so Drug 3 is less selective (a true).
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