JEE Main levelSingle correct optionDifficulty 2 of 3el017
The inhibition of an enzyme by compound I is not reduced when the substrate concentration is raised 100-fold, and I has no structural resemblance to the substrate. Most likely I is
Aan allosteric (non-competitive) inhibitor binding away from the active site
Ba competitive inhibitor binding the active site
Ca substrate analogue that occupies the active site
Da receptor agonist
Answer: A
Competitive inhibition can be overcome by excess substrate. If it cannot, the inhibitor is not competing for the active site. Lack of resemblance to the substrate points to binding at a different (allosteric) site.