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JEE Main levelOne or more correct optionsDifficulty 2 of 3el020

Select all correct statements about competitive enzyme inhibitors.

  1. AThey usually resemble the substrate structurally.
  2. BThey bind at the active site.
  3. CTheir effect cannot be lowered by adding more substrate.
  4. DThey bind at a site remote from the active site and distort it.

Answer: A, B

A competitive inhibitor mimics the substrate and sits in the active site, so (a) and (b) are true. Because it competes with the substrate, excess substrate reduces its effect, so (c) is false. Binding at a remote site is allosteric, so (d) is false.
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