Assertion (A): Every drug that works by inhibiting an enzyme must bind it through covalent bonds. Reason (R): Covalent binding of an inhibitor at the active site makes the inhibition irreversible under normal conditions. Choose the correct option.

ABoth A and R are true and R is the correct explanation of A
BBoth A and R are true but R is not the correct explanation of A
CA is true but R is false
DA is false but R is true

Answer: D

A is false: competitive and allosteric inhibitors commonly bind by weak, reversible interactions. R is true: a covalently attached inhibitor is not released, so the enzyme molecule stays inactive.

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