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JEE Advanced levelOne or more correct optionsDifficulty 3 of 3el033

Select all correct statements about enzyme inhibitors.

  1. AAn allosteric inhibitor need not resemble the substrate.
  2. BA competitive inhibitor loses effectiveness as the substrate concentration is raised.
  3. CAn allosteric inhibitor works by binding inside the active site.
  4. DCovalent binding of an inhibitor to the active site can be reversed simply by adding more substrate.

Answer: A, B

Allosteric inhibitors bind a separate site, so they need not resemble the substrate (a true) and do not enter the active site (c false). Competitive inhibition is lowered by excess substrate (b true). A covalently bound inhibitor is not displaced by substrate (d false).
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