Assertion: Hofmann bromamide degradation of an optically active amide R-CONH2 in which R is chiral at the carbon attache

Question

Assertion: Hofmann bromamide degradation of an optically active amide R-CONH2 in which R is chiral at the carbon attached to C=O gives an amine of retained configuration. Reason: The R group migrates from carbon to nitrogen with inversion of configuration while forming the isocyanate.

Accepted Answer

Assertion is true but Reason is false

Answer

Both Assertion and Reason are true and the Reason is the correct explanation of the Assertion

Answer

Assertion is false but Reason is true

Answer

Both Assertion and Reason are true but the Reason is not the correct explanation of the Assertion

Assertion: Hofmann bromamide degradation of an optically active amide $R - CONH X_{2}$ in which R is chiral at the carbon attached to C=O gives an amine of retained configuration. Reason: The R group migrates from carbon to nitrogen with inversion of configuration while forming the isocyanate.

Answer: B

More questions on Preparation of amines: Gabriel, Hofmann bromamide, reduction routes

Assertion: Hofmann bromamide degradation of an optically active amide R−CONHX2​ in which R is chiral at the carbon attached to C=O gives an amine of retained configuration. Reason: The R group migrates from carbon to nitrogen with inversion of configuration while forming the isocyanate.

Answer: B

More questions on Preparation of amines: Gabriel, Hofmann bromamide, reduction routes

Assertion: Hofmann bromamide degradation of an optically active amide $R - CONH X_{2}$ in which R is chiral at the carbon attached to C=O gives an amine of retained configuration. Reason: The R group migrates from carbon to nitrogen with inversion of configuration while forming the isocyanate.