N,N,N,2-Tetramethylbutan-2-aminium hydroxide, $\mathrm{CH}{}_3\mathrm{CH}{}_2\mathrm{C}(\mathrm{CH}{}_3){}_2-\mathrm{N}{}^{+}(\mathrm{CH}{}_3){}_3\mathrm{OH}{}^{-}$, is heated. The major alkene formed is:

In Hofmann elimination the hydrogen removed is the least hindered and most acidic one: a methyl hydrogen on C2 is preferred over the methylene hydrogen. This gives $\mathrm{CH}{}_2=\mathrm{C}(\mathrm{CH}{}_3)\mathrm{CH}{}_2\mathrm{CH}{}_3$ (2-methylbut-1-ene) and trimethylamine, the opposite of Saytzeff orientation.