NEET levelSingle correct optionDifficulty 1 of 3o4168
In the E2 reaction of a chlorocyclohexane derivative, the chlorine and the beta-hydrogen that is removed must be:
Atrans and both equatorial
Bcis, one axial and one equatorial
Ctrans and both axial (trans-diaxial)
Dboth on the same carbon atom
Answer: C
The anti-periplanar requirement in a chair is met only by two trans axial bonds on adjacent carbons (dihedral 180∘). Equatorial bonds, or cis axial/equatorial pairs, make dihedral angles of about 60∘ and cannot undergo E2.