Answer: B, C, D
Under basic conditions, ring opening is SN2 at the less hindered carbon, here CHX2. The stereocentre keeps all four of its bonds, so its geometry is retained. Its priorities become OH>CHX2OCHX3>CHX3>H, the same order as before, so the descriptor remains S. The last option corresponds to attack at the more hindered carbon, which is characteristic of acidic conditions.