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JEE Main levelSingle correct optionDifficulty 2 of 3g3181

For 2-methylcyclohexan-1-one, the thermodynamic (more substituted) enolate is favoured by

  1. Aany strong base at any temperature, since the ratio is always the same
  2. BLDA in THF at with short reaction time
  3. CNaOEt in ethanol at , where proton transfers equilibrate the enolates
  4. DLDA in THF at followed by immediate quench with

Answer: C

A weak base in a protic solvent makes deprotonation reversible. The enolates equilibrate and the more stable, more substituted one predominates. Irreversible LDA conditions at give the kinetic enolate.
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