Which hydrogen of the compound shown is the most acidic?

Athe amide N-H
Bthe CH3 hydrogens
Cthe phenolic O-H
Dthe ring C-H hydrogens

Answer: C

The compound is 4-acetamidophenol (paracetamol). The phenolic O-H (pKa about 9.5) is more acidic than the amide N-H (about 15 or above) and the acetyl CH3 (about 26).

Practice General Organic Chemistry II: Acids and Bases More on Most acidic hydrogen in drawn molecules

Previous questionNext question

More questions on Most acidic hydrogen in drawn molecules

Which hydrogen atoms of the compound shown are the most acidic? JEE Main level
In the compound shown, count the sets of chemically equivalent hydrogen atoms whose pKa is below 12. Use these approximate values: carboxyli... JEE Advanced level
The compound shown is a beta-ketoester. Select ALL the correct statements. JEE Main level
Which hydrogens of the compound shown are the most acidic? JEE Main level
Which hydrogen of the compound shown (a lactone-based enediol) is the most acidic? JEE Advanced level
Which hydrogens of the compound shown are the most acidic? JEE Advanced level