Answer: C
Both are D-aldohexoses and differ only at C-2 (the C-2 labels are R and S while C-3 to C-5 are the same). Sugars differing at a single stereocentre other than the anomeric one are epimers; these are D-glucose and D-mannose, C-2 epimers. Anomers differ at the new centre formed on ring closure.