JEE Advanced levelSingle correct optionDifficulty 3 of 3bm131
Two inhibitors are tested on an enzyme. With inhibitor X the rate at very high [S] reaches the same plateau as without inhibitor, although a higher [S] is needed. With inhibitor Y the plateau rate is lowered and raising [S] does not restore it. The best conclusion is
AX is competitive and Y is non-competitive
BX is non-competitive and Y is competitive
Cboth X and Y are competitive
Dboth X and Y are non-competitive
Answer: A
A competitive inhibitor is outcompeted by excess substrate, so the maximum rate is regained. A non-competitive inhibitor binds elsewhere and lowers the number of active enzyme molecules, so the plateau cannot be restored by more substrate.