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JEE Advanced levelSingle correct optionDifficulty 3 of 3bm131

Two inhibitors are tested on an enzyme. With inhibitor X the rate at very high reaches the same plateau as without inhibitor, although a higher is needed. With inhibitor Y the plateau rate is lowered and raising does not restore it. The best conclusion is

  1. AX is competitive and Y is non-competitive
  2. BX is non-competitive and Y is competitive
  3. Cboth X and Y are competitive
  4. Dboth X and Y are non-competitive

Answer: A

A competitive inhibitor is outcompeted by excess substrate, so the maximum rate is regained. A non-competitive inhibitor binds elsewhere and lowers the number of active enzyme molecules, so the plateau cannot be restored by more substrate.
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