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JEE Advanced levelOne or more correct optionsDifficulty 3 of 3bm107

Which of the following pairs of side chains can stabilise tertiary structure through the stated interaction?

  1. Acysteine and cysteine: disulfide bridge
  2. Bvaline and leucine: hydrophobic interaction
  3. Clysine () and aspartic acid (): ionic (salt) bridge
  4. Dalanine and valine: ionic bridge

Answer: A, B, C

Cys-Cys forms a covalent bond; the oppositely charged side chains of Lys and Asp attract each other; the non-polar isopropyl and isobutyl groups of Val and Leu cluster together. Alanine and valine have uncharged side chains so cannot form an ionic bridge.
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