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JEE Advanced levelOne or more correct optionsDifficulty 3 of 3sc105

Select all correct statements about enzyme inhibition.

AIn competitive inhibition $V_{ma x}$ is unchanged.
BIn competitive inhibition the apparent $K_{m}$ decreases.
CIn pure non-competitive inhibition $V_{ma x}$ decreases while $K_{m}$ is unchanged.
DCompetitive inhibition can be reduced by increasing the substrate concentration.

Answer: A, C, D

A competitive inhibitor raises the apparent

K_{m}

(B false) but

V_{ma x}

is reached at high

[S]

, where the inhibitor is outcompeted (A and D true). A non-competitive inhibitor removes active enzyme, lowering

V_{ma x}

with

K_{m}

unchanged (C true).

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