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Organic Reaction Mechanisms IV: Elimination
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E1cB mechanism
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o4038
In an E1cB elimination, the sequence of events is
A
loss of the leaving group first, then proton removal
B
loss of the proton and the leaving group simultaneously
C
loss of the leaving group, then attack of a nucleophile
D
proton removal first, then loss of the leaving group
Answer: D
In E1cB the acidic beta-hydrogen is removed first by the base to give a carbanion; the leaving group departs in a second step from the carbanion.
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