Count the distinct 1H NMR environments in the drug shown, treating the CH3 group as one environment, the two ring protons ortho to each substituent as equivalent, and the NH and OH protons as separate environments (topological symmetry only). Give the number as an integer.

Numerical answer type, tolerance 0.5.

Answer: 5

The compound shown is paracetamol. Distinct H environments: CH3, NH, OH, the two ring H next to NHCOCH3 and the two ring H next to OH. That is 1 + 1 + 1 + 1 + 1 = 5 (confirmed by RDKit canonical ranks).

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Count the distinct 1H NMR environments in the drug shown, treating the CH3 group as one environment, the two ring protons ortho to each substituent as equivalent, and the NH and OH protons as separate environments (topological symmetry only). Give the number as an integer.

Answer: 5

More questions on Functional groups and drug class from drawn drug structures