JEE Advanced levelSingle correct optionDifficulty 3 of 3bm157
A linear double-stranded DNA is 12 base pairs long, with one strand 5′-GCGAATTCGCGC-3′. Count each phosphodiester bond in both strands (A-T = 2 and G-C = 3 hydrogen bonds). The sum of the number of hydrogen bonds and the number of phosphodiester bonds is
A44
B56
C54
D46
Answer: C
GC pairs: 8, AT pairs: 4, so hydrogen bonds = 8×3+4×2=32. Each strand of 12 nucleotides has 11 phosphodiester bonds, so 22 in all. Sum = 32+22=54.